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See Latest ArticlesPsychological therapies in bipolar disorder: the effect of illness history on relapse prevention – a systematic review
Bipolar Disorders, 07/15/09
Lam DH et al. - Psychological therapy specifically designed for bipolar disorder is effective in preventing or delaying relapses in bipolar disorders, and there is no clear evidence that the number of previous episodes moderated the effect.
Methods- Systematic literature searches of electronic databases and reference lists of existing reviews were carried out.
- The number of participants experiencing relapse in randomized, controlled studies was combined in a meta-analysis to determine the overall treatment effect in relapse prevention.
- Metaregression modeling was used to examine whether the number of previous episodes confounded the number of relapses experienced by participants by the end of treatment.
- Meta-analysis of relapse calculated an overall relative risk of 0.74 [95% confidence interval (CI): 0.64–0.85] with some heterogeneity present (I2 = 43.3%).
- Metaregression of six studies showed no relationship between number of episodes and number of relapses by endpoint.
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