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See Latest ArticlesChildhood neglect and abuse as predictors of antidepressant response in adult depression
Depression and Anxiety, 06/24/09
Johnstone JM et al. - The experience of having a neglectful father or an overprotective mother was more predictive of response to treatment for depression than abuse, suggesting that the quality of ongoing intra-familial relationships has a greater impact on treatment outcomes for depression than experiences of discrete abuse in childhood.
Methods- Clinically depressed outpatients (n=195) were asked about childhood experiences before beginning a randomized antidepressant trial with either fluoxetine or nortriptyline.
- Three treatment outcomes were measured: Adequate trial, six-week response and two months sustained recovery.
- Patients reporting low paternal care (paternal neglect), as measured by the Parental Bonding Instrument (PBI), were less likely to complete an adequate six-week trial of medication.
- Patients who reported high maternal protection (maternal overprotection) on the PBI had poorer treatment response in the short-term at six weeks, and longer term, for two months of sustained recovery.
- However, abuse, whether sexual, physical, or psychological in nature, did not predict treatment response.
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