Your Article Summary
See Latest ArticlesTreatment of fibromyalgia syndrome with gabapentin and pregabalin – A meta-analysis of randomized controlled trials
Pain, 06/22/09
Häuser W et al. - Study concludes that the usage of gabapentin (GPT) and pregabalin (PGB) can be considered for the treatment of pain and sleep disturbances in FMS patients. Because of some dose-dependent relevant side effects of both drugs the treatment should start with low dosage and then increased slowly with small dosages.
Methods- Aim of this systematic review and meta-analysis was to determine the clinical relevance of GPT/PGB for the treatment of FMS
- MEDLINE, PsycINFO, SCOPUS, www.clinicaltrials.org, the Cochrane Library (through October 2008), and the reference sections of original studies on GPT/PGB in FMS were searched
- Randomized controlled trials (RCTs) on the treatment of FMS with GPT and PGB were analyzed
- 6/127 RCTs studying 2422 subjects on treatment with GPT (1 study) or PGB (5 studies) and 1056 subjects on placebo with a median treatment duration of 11wks were included
- Strong evidence for a reduction of pain, improved sleep and improved health-related quality of life (HRQOL) but not for depressed mood
- There was strong evidence for a non-substantial reduction of fatigue and of anxiety
- The external validity of the studies was limited because pts with severe somatic and mental disorders were excluded
Related Articles
Are chronic fatigue syndrome and fibromyalgia the same? Implications for the provision of appropriate mental health intervention
Journal of Psychiatric and Mental Health Nursing, 11/16/09
Relevance Score: 69%
The Predetermined Sites of Examination for Tender Points in Fibromyalgia Syndrome Are Frequently Associated With Myofascial Trigger Points
The Journal of Pain, 11/17/09
Relevance Score: 68%
Fibromyalgia and Myofascial Pain Syndrome - A Dilemma
Indian Journal of Anaesthesia, 10/22/09
Relevance Score: 68%
Sleep Apnea and Psychological Functioning in Chronic Fatigue Syndrome
Journal of Health Psychology, 11/04/09
Relevance Score: 67%
Patients' experiences of living with and receiving treatment for fibromyalgia syndrome: a qualitative study
BMC Musculoskeletal Disorders, 10/08/09
Relevance Score: 67%
Today in Mood Disorders...keeping you current
Receive free subspecialty "5-minute updates" via email
Ethnic differences in antidepressant response: a prospective multi site clinical trial
Depression and Anxiety, 12/09/09
Is pregnancy associated with mood and anxiety disorders? A cross-sectional study
General Hospital Psychiatry, 12/09/09
Empirical typology of bipolar I mood episodes
British Journal of Psychiatry, 12/09/09
Today in Neuro/Psych Pharmacol...keeping you current
Receive free subspecialty "5-minute updates" via email
Update on the management of attention-deficit/hyperactivity disorder in children and adults: patient onsiderations and the role of lisdexamfetamine
Therapeutics and Clinical Risk Management, 12/09/09
A Preliminary Controlled Trial of Cognitive Behavioral Therapy in Clozapine-Resistant Schizophrenia
The Journal of Nervous and Mental Disease, 12/09/09
Psychophysiological disorders among buprenorphine patients
International Journal of Psychiatry in Clinical Practice, 12/09/09
Today in Other Psychiatry...keeping you current
Receive free subspecialty "5-minute updates" via email
Sleep problems as reported by parents in Swedish children and adolescents with obsessive-compulsive disorder (OCD), child psychiatric outpatients and school children
Nordic Journal of Psychiatry, 12/10/09
Screening of psychiatric outpatients for borderline personality disorder with the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD)
Nordic Journal of Psychiatry, 12/10/09
A Preliminary Controlled Trial of Cognitive Behavioral Therapy in Clozapine-Resistant Schizophrenia
The Journal of Nervous and Mental Disease, 12/09/09