Your Article Summary
See Latest ArticlesRapid-cycling bipolar I disorder: Course and treatment outcome of a large sample across Europe
Journal of Psychiatric Research, 06/25/09
Cruz N et al. - The EMBLEM results suggest that in naturalistic settings, patients with mania and RC differ from NRC in socio-demographic characteristics, treatment prescriptions and clinical outcome measures with a consistently worse occupational outcome and comorbidities. RC represents a longitudinally severe form of bipolar disorder, with poorly evidence-based diagnostic and therapeutic tools.
Methods- EMBLEM (European Mania in Bipolar Longitudinal Evaluation of Medication) is a long-term prospective observational study of in- and outpatients with an acute mania/mixed episode conducted in 14 European countries.
- Demographic and clinical variables were collected at baseline, including the presence or absence of DSM-IV rapid-cycling during the past year.
- Outcome measures included the 5-item Hamilton Depression Rating Scale (HAMD-5) and Young Mania Rating Scale (YMRS) over 12 weeks, as well as the Clinical Global Impressions-Bipolar Disorder Scale (CGI-BP overall, mania and depression) over 12 months.
- Of 3684 patients enrolled, 3089 patients provided reliable data to qualify for either RC (N = 535, 17.3%) or non-RC (NRC, N = 2554), according to DSM-IV.
- RC prevalence varied across countries (p < 0.001).
- Baseline and 12 week outcomes on the YMRS and HAMD-5, 12 month ratings on the CGI-BP subscales and work impairment at 12 months were significantly different (p < 0.001) between groups, being worse in RC.
- RC patients were more likely to receive antidepressants and lamotrigine (p < 0.001).
- Using logistic regression, RC was associated to country (p < 0.001), female sex (p = 0.029), outpatients (p = 0.035), more history of attempted suicide (p < 0.001) and alcohol abuse (p < 0.001).
Related Articles
Is Monotherapy as Good as Polypharmacy in Long-Term Treatment of Bipolar Disorder
Canadian Journal of Psychiatry, 11/16/09
Relevance Score: 66%
Bipolar Disorder Patient Care Opportunities: Let's Answer the Call
Annals of Pharmacotherapy, 10/16/09
Relevance Score: 46%
Safety and Efficacy of Quetiapine in Bipolar Depression
Annals of Pharmacotherapy, 10/13/09
Relevance Score: 46%
Subgenual cingulate volumes in offspring of bipolar parents and in sporadic bipolar patients
European Archives of Psychiatry and Clinical Neuroscience, 10/13/09
Relevance Score: 46%
The role of dopamine in bipolar disorder
Bipolar Disorders, 11/19/09
Relevance Score: 45%
Today in Mood Disorders...keeping you current
Receive free subspecialty "5-minute updates" via email
Cannabis and suicide: longitudinal study
British Journal of Psychiatry, 12/15/09
An endocrine perspective on the role of steroid hormones in the antidepressant treatment efficacy of transcranial magnetic stimulation
Psychoneuroendocrinology, 12/15/09
Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
Journal of Psychopharmacology, 12/15/09
Today in Neuro/Psych Pharmacol...keeping you current
Receive free subspecialty "5-minute updates" via email
Reported Allergies to Antipsychotic Agents in a Long-Term Psychiatric Hospital
Journal of Psychiatric Practice, 12/15/09
An endocrine perspective on the role of steroid hormones in the antidepressant treatment efficacy of transcranial magnetic stimulation
Psychoneuroendocrinology, 12/15/09
Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
Journal of Psychopharmacology, 12/15/09
Today in Neuro/Psych Pharmacol...keeping you current
Receive free subspecialty "5-minute updates" via email
Reported Allergies to Antipsychotic Agents in a Long-Term Psychiatric Hospital
Journal of Psychiatric Practice, 12/15/09
An endocrine perspective on the role of steroid hormones in the antidepressant treatment efficacy of transcranial magnetic stimulation
Psychoneuroendocrinology, 12/15/09
Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
Journal of Psychopharmacology, 12/15/09