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Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder
Journal of Affective Disorders, 06/24/09

Brietzke E et al. - These findings suggest that mania, and to a less extent, depression are associated with a proinflammatory state. These changes seem to be related to mood state, as changes in cytokine profile were more pronounced during acute episodes than in euthymia. This study provides further support to investigate the immune system as a target for future treatment development.

Methods

Sixty-one bipolar patients were recruited for assessment of serum cytokine levels.
Of these, 14 were in euthymic state, 23 and 24 were in manic and depressive episodes, respectively.
A healthy comparison group included 25 healthy volunteers.
Cytokines involved in Th1/Th2 balance, such as TNF- α, IL-2, IL-4, IL-6, IL-10, IFN- &gamma, were examined by flow cytometry.

Results

During mania, proinflammatory cytokines, IL-2, IL-4 and IL-6, were increased in comparison with healthy subjects.
Patients in depressive episode showed only increased IL-6 levels. There were no significant differences in cytokine levels between patients in remission and healthy subjects, except for IL-4.
Mood symptoms showed a positive correlation with IL-6 and IL-2.

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