Psychiatry Medical News about Diazepam Fluoxetine

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Co-Treatment with Diazepam Prevents the Effects of Fluoxetine on the Proliferation and Survival of Hippocampal Dentate Granule Cells
Biological Psychiatry, 06/19/09

Wu X et al. - These results suggest that benzodiazepines might interfere with the clinical effects of fluoxetine or that increased neurogenesis is not a valid model for the delayed onset of the clinical antidepressant effects.

Methods

Used this delayed increase in neurogenesis, as detected with both a rapid dot-blot method and with immunostaining, as a model of the delayed clinical antidepressant effects.

Results

Whereas the SSRI fluoxetine alone significantly increased both neurogenesis and survival of newborn cells when administered for 2–3 weeks, co-treatment with diazepam and fluoxetine completely blocked the increase in both neurogenesis and survival.
Furthermore, neurogenesis was not increased when fluoxetine and diazepam were first co-administered for 2 weeks and then fluoxetine was given alone for 2 additional weeks.
Moreover, this study shows that daily administration is necessary for neurogenesis, because injection of fluoxetine for up to 1 week failed to increase neurogenesis, when assayed at 14 days from the first injection.

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