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See Latest ArticlesRelapse rates with long-term antidepressant drug therapy: a meta-analysis
Human Psychopharmacology: Clinical and Experimental, 06/17/09
Williams N et al. - Prophylactic antidepressant drug therapy appears efficacious in preventing future relapses across a range of illness severity as well as age. More studies are needed to explore the effects of various acute antidepressant strategies and the direct influence of treatment resistance on relapse outcomes.
Methods- Performed a comprehensive literature search.
- The extracted data from selected studies were used to construct a regression model and evaluate the effect of treatment, time on medication, severity of illness, age, gender, and number of previous episodes.
- Across 11 maintenance treatment studies, the relapse rate was significantly different at 1 year for active drug (23%) versus placebo (51%).
- In addition, time on medication significantly affected the relapse rate.
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