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Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers
Journal of Psychopharmacology, 06/10/09

Winder-Rhodes SE et al. - The current data suggest that the cognitive effects of modafinil on performance accuracy and latency are dissociable in terms of their neurochemical mechanisms. This study's findings support the hypothesised involvement of 1-adrenoceptors in some of the cognitive-enhancing effects of modafinil and warrant further investigation.

• double-blind, placebo-controlled study,
• 12 healthy male adults received modafinil (300 mg), the 1-adrenoceptor antagonist prazosin (3 mg), both together and placebo on separate occasions at least 5 days apart.
• Cognitive effects were assessed using a well-validated testing battery focusing on executive and working memory functions.
• Blood pressure, heart rate and salivary -amylase (sAA) were measured at hourly intervals.
• Cognitive effects of modafinil and prazosin were identified at the difficult levels of the One-Touch Stockings of Cambridge (OTSOC) planning task.

• Prazosin antagonized the error-reducing effect of modafinil when the agents were given together.
• In contrast, the combined agents acted synergistically to increase time taken to complete OTSOC problems compared with placebo.

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