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See Latest ArticlesEffects of major depression diagnosis and cortisol levels on indices of neurocognitive function
Psychoneuroendocrinology, 06/04/09
Gomez RG et al. - This study suggests that cortisol has an independent effect on verbal memory. Also, the study produced evidence of an interaction between diagnosis and cortisol on response inhibition.
Methods- Thirty-seven unmedicated nondelusional MDs and 18 HCs underwent psychiatric ratings, hourly assessments of cortisol activity over 24 h, and neuropsychological assessments.
- Hierarchical multiple regressions indicated a significant effect of cortisol but not of diagnosis on verbal memory
- Greater cortisol levels were related to poorer memory performance independent of group.
- In contrast, a significant interaction between cortisol and diagnosis was found for a color-word index of response inhibition.
- This interaction suggests that the detrimental effect of elevated cortisol level on this type of executive functioning exists only in the healthy control group but not in MDs.
- On an Interference score, another measure of response inhibition, cortisol had a significant independent effect, but neither the effects of diagnosis and the interaction attained full significance.
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