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A single-blind, randomized, crossover trial of the effects of a nicotine pouch on the relief of tobacco withdrawal symptoms and user satisfaction
Nicotine & Tobacco Research, 05/21/09

Thornley S et al. - The Zonnic pouch appears to be as effective at relieving craving as nicotine gum and was subjectively favored over the gum. These results suggest that the pouch will be a helpful addition to the range of existing nicotine replacement treatments.

• This was a randomized, placebo-controlled, three-way crossover study of 30 adult smokers.
• After overnight tobacco abstinence, subjects reported on a Visual Analog Scale (VAS; 0–100) tobacco withdrawal symptoms (craving, irritability, difficulty concentrating, and restlessness) before use and during the first hour after first product use.
• Used the product throughout the study day and in the evening reported product usefulness, temporary abstinence success, and satisfaction.

• In a multivariate analysis, area under the curve (craving vs. time) was reduced by 23 points 60 min after taking the study medication in the nicotine pouch group, compared with 15- and 8-point decreases in the gum and placebo groups, respectively.
• The difference in craving ratings between the pouch and placebo was significant (p = .002).
• Nicotine pouch reduced irritability more than gum (difference = 9.86; p = .01).
• For pouch users, the odds ratio for temporary tobacco abstinence (21.5 hr) during study days (compared with gum) was 2.8 (95% CI = 0.8–8.1).
• Compared with the gum, the pouch was rated as significantly more "helpful to stop smoking" (difference = 20.6; 95% CI = 2.4–38.9) and "pleasant to use" (difference = 17.3; 95% CI = 2.6–32.0).

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