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Use of antipsychotics in neuropsychiatric symptoms of dementia
Geriatrics, 05/18/09
Kalapatapu RK et al. - Antipsychotic medications have a modest effect on the neuropsychiatric symptoms of dementia, but product labels warn of the excess risk of death and morbidity associated with their use in older patients. As such, these agents should not be the first choice for the treatment of behavioral and psychotic symptoms of dementia. Nevertheless, a trial of these agents may be indicated in instances in which the severity of symptoms is extreme, or symptoms do not respond to nonpharmacologic methods or other medications...There is no evidence to suggest differences in effectiveness between atypical and conventional antipsychotics; therefore, the choice of an antipsychotic for neuropsychiatric symptoms often relies on side effect profile and individual patient circumstances. Extrapyramidal symptoms and QTc prolongation are concerns with conventional antipsychotic agents. The incidence of cerebrovascular events with either atypical or conventional antipsychotics appears increased compared with placebo. A discussion of the risk-benefit ratio of antipsychotics with the patient's family and/or caregivers should precede the decision to use these agents.
Today in Geriatric Psych...keeping you current
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Management of agitation and aggression associated with Alzheimers disease: controversies and possible solutions
Current Opinion in Psychiatry, 10/12/09
Green tea consumption is associated with depressive symptoms in the elderly
American Journal of Clinical Nutrition, 10/15/09
Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias
Clinical Interventions in Aging, 09/29/09
Today in Neuro/Psych Pharmacol...keeping you current
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Estimation of clonazepam abuse liability: a new method using a reimbursed drug database
International Clinical Psychopharmacology, 10/20/09
Asenapine versus olanzapine in acute mania: a double-blind extension study
Bipolar Disorders, 10/22/09
Does Dual Antidepressant Therapy as Initial Treatment Hasten and Increase Remission from Depression
Journal of Psychiatric Practice, 09/29/09
Today in Neuropsych Sciences...keeping you current
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A comparison of serum prolactin concentrations after administration of paliperidone extended-release and risperidone tablets in patients with schizophrenia
Journal of Psychopharmacology, 10/19/09
Predictive factors for responding to sertraline treatment: views from plasma catecholamine metabolites and serotonin transporter polymorphism
Journal of Psychopharmacology, 10/20/09
Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias
Clinical Interventions in Aging, 09/29/09
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