Protein Kinase C Inhibitors: Rationale for Use and Potential in the Treatment of Bipolar Disorder Zarate CA et al. - Importantly, the current mainstays in the treatment of mania, lithium (a monovalent cation) and valproate (a small fatty acid) indirectly inhibit PKC. In addition, recent clinical studies with the relatively selective PKC inhibitor tamoxifen add support to the relevance of the PKC target in bipolar disorder. [more...]
