Risk of lipid abnormality with haloperidol, olanzapine, quetiapine, and risperidone in a Veterans Affairs population
Duncan EJ et al. - Treatment with risperidone or haloperidol was associated with a more favorable lipid profile than with olanzapine or quetiapine. Methods- Computerized, retrospective, nonrandomized, case-control analysis of 6331 patients receiving antipsychotics.
- For each patient, the first prescription for at least 60 continuous days for four antipsychotics [haloperidol (HALD), olanzapine (OLANZ), quetiapine (QUET), or risperidone (RISP)] was analyzed for total cholesterol, low-density lipoprotein, high-density lipoprotein (HDL), and triglycerides (TGL).
Results- Mean HDL was lower during OLANZ treatment than with RISP (P = 0.03) or QUET (P = 0.001).
- TGL were higher during OLANZ (P = 0.0007) or QUET treatment (P = 0.006) than RISP.
- percentage of participants having abnormal cholesterol (P = 0.0003), low-density lipoprotein (P = 0.001), or TGL (P = 0.0001) during medication were in the order: OLANZ > QUET > RISP > HALD.
- For HDL, the results were less robust but the percentage of participants were in the order: OLANZ>RISP = HALD = QUET.
- There was a greater risk of developing new HDL abnormality with OLANZ than RISP (P<0.05).
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