A comparison of low-dose risperidone to paroxetine in the treatment of panic attacks: a randomized single-blind study.
Prosser JM et al. - This study can identify no difference in the efficacy of paroxetine and low-dose risperidone in the treatment of panic attacks. Low-dose risperidone appears to be tolerated equally well as paroxetine. Low-dose risperidone may be an effective treatment for anxiety disorders in which panic attacks are a significant component. Methods- Fifty six subjects with a history of panic attacks were randomized to receive either risperidone or paroxetine.
- The subjects were then followed for eight weeks.
- Outcome measures included the Panic Disorder Severity Scale (PDSS), the Hamilton Anxiety Scale (Ham-A), the Hamilton Depression Rating Scale (Ham-D), the Sheehan Panic Anxiety Scale-Patient (SPAS-P), and the Clinical Global Impression scale (CGI).
Results- All subjects demonstrated a reduction in both the frequency and severity of panic attacks regardless of treatment received.
- Statistically significant improvements in rating scale scores for both groups were identified for the PDSS, the Ham-A, the Ham-D, and the CGI.
- There was no difference between treatment groups in the improvement in scores on the measures PDSS, Ham-A, Ham-D, and CGI.
- Post hoc tests suggest that subjects receiving risperidone may have a quicker clinical response than subjects receiving paroxetine.
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