Top ssri Articles in Psychiatry

Preadmission use of SSRIs alone or in combination with NSAIDs and 30-day mortality after peptic ulcer bleeding
Scandinavian Journal of Gastroenterology, 11/06/2009

Gasse C et al. – Use of SSRIs, alone or in combination with NSAIDs, was not associated with increased 30–day mortality following PUB. However, increased mortality was found in ... started SSRI therapy, particularly among those older than 80 years. [more...]

Antidepressant use and colorectal cancer risk
Pharmacoepidemiology and Drug Safety, 09/14/2009

risk of colorectal cancer with regular use of SSRIs. In light of laboratory data indicating that SSRIs may inhibit colon cancer and one previous epidemiologic study that also observed a decreased risk, further investigation of the effect of SSRIs on the risk of colorectal cancer is warranted [more...]

Sustained Neurobehavioral Effects of Exposure to SSRI Antidepressants During Development: Molecular to Clinical Evidence
Clinical Pharmacology & Therapeutics, 11/10/2009

Oberlander TF et al. – Preclinical studies report enduring molecular, physiological, and behavioral consequences of developmental SSRI exposure. In humans, sustained developmental ... distinguishing between the effects of prenatal SSRI exposure and the impact of maternal mental illness remains a key challenge. [more...]

Trends in prescribing and self-poisoning in relation to UK regulatory authority warnings against use of SSRI antidepressants in under-18-year-olds
British Journal of Clinical Pharmacology, 11/02/2009

Bergen H et al. – The reduction in both prescribing and self–poisoning with SSRI antidepressants (except fluoxetine) following the MHRA warning is in keeping with ... from other SSRIs to fluoxetine for use in self–poisoning. Importantly, overall rates of nonfatal self–harm and self–poisoning did not change, indicating no substitution of method or increases in self–injury. [more...]

5HT1A-mediated stimulation of cortisol release in major depression: use of non-invasive cortisol measurements to predict clinical response
European Archives of Psychiatry and Clinical Neuroscience, 08/11/2009

of a 5HT1A–selective agonist predicted treatment outcome following an 8–week, fixed–dose, open–label trial of the SSRI escitalopram among outpatients with MDD. Although the 5HT1A–desensetization hypothesis is still a valid one, the results of the present study could not ... dose of the 5HT1A–selective agonist buspirone, predicted treatment outcome following an 8–week, fixed–dose, open trial of the SSRI escitalopram in 17 outpatients with MDD. Results Change in cortisol levels before and 90 min after the administration of [more...]

Are selective serotonin reuptake inhibitors cardiac teratogens? Echocardiographic screening of newborns with persistent heart murmur
Birth Defects Research, 08/26/2009

Klinger G et al. – Newborns exposed in utero to SSRIs, have a twofold higher risk of mild nonsyndromic heart defects than unexposed infants. The data suggest that women who require SSRI treatment during pregnancy can be reassured that the fetal risk is low and [more...]

Subchronic SSRI administration reduces insula response during affective anticipation in healthy volunteers
International Journal of Neuropsychopharmacology, 08/14/2009

Simmons AN et al. – The authors found that escitalopram significantly decreased activation in bilateral posterior and middle insula during the anticipation condition irrespective of ... vs. pleasant images. Reduced insular and ACC activation in healthy controls during anticipation may be integral to the therapeutic efficacy of SSRIs and may provide a mechanistic approach for the use of pharmaco–fMRI in the identification of novel pharmacotherapeutic agents in patient [more...]

Physical and psychosocial functioning following motor vehicle trauma: Relationships with chronic pain, posttraumatic stress, and medication use
European Journal of Pain, 08/13/2009

ndash;pain was associated with greater impairment among opioid users, (4) SSRIs held a marginal interaction with PTSD such that PTSD was related to poorer psychosocial functioning only among individuals not using an SSRI, and (5) Anxiolytic use evidenced a marginal interaction with PTSD on physical [more...]

Clinical study on combined needle-embedding and medication for depressive sleep disorder
Journal of Acupuncture and Tuina Science, 08/24/2009

Wang TJ et al. – SSRIs can improve HAMD sleep scores. The combined needle–embedding or acupuncture with SSRIs can work faster and better than medication alone. There was no statistical difference between needle [more...]

Sexual side-effects of contemporary antidepressants: review
Australian and New Zealand Journal of Psychiatry, 08/12/2009

the SSRIs in short–term studies and reboxetine significantly less in both short– and longer term studies. Bupropion and agomelatine caused significantly less sexual dysfunction than venlafaxine. The evidence for mirtazepine having an advantage over the SSRIs is lacking [more...]