Increased Amygdala Response to Positive Social Feedback in Young People with Major Depressive Disorder

Biological Psychiatry, 02/08/2011

Studies of depressed patients have demonstrated increased amygdala activation to negative affective stimuli. Depressed patients responded to positive social feedback with increased amygdala activation, demonstrating that amygdala hyperresponsivity in depression is not restricted to negatively–valenced stimuli. The heightened sensitivity of depressed participants to social evaluation may help explain symptoms of depression such as social withdrawal.

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