Increased risk of hypertension in patients with major depressive disorder: A population-based study
Journal of Psychosomatic Research, 07/25/2012
Wu EL et al. – Patients with major depressive disorder (MDD) had a higher prevalence and a higher incidence of hypertension than that in the general population. Age, male gender, and antipsychotic use were risk factors for hypertension among patients with MDD.Methods
- The National Health Research Institute provided a database of 1,000,000 random subjects for study.
- The authors obtained a random sample of 766,427 subjects, aged ≥18years in 2005.
- Study subjects had at least one service claim during 2005 for either outpatient or inpatient care with a primary diagnosis of MDD or with a primary or secondary diagnosis of hypertension and combined with antihypertensive drug treatment were identified.
- The authors also compared the incidence of hypertension among patients with MDD and the general population from 2006 through 2008.
- The 1–year prevalence of hypertension in patients with MDD was higher than that in the general population (21.21% vs. 13.28%, risk ratio, 1.22; 95% confidence interval, 1.17–1.28).
- Compared with the general population, patients with MDD had a higher prevalence of hypertension in all age, sex, insurance amount, region, and urbanicity groups.
- The average annual incidence of hypertension in patients with MDD from 2006 to 2008 was higher than that in the general population (3.96% vs. 2.90%, risk ratio, 1.19; 95% confidence interval, 1.08–1.31).
- Compared with the general population, patients with MDD had a higher incidence of hypertension in all age, and male groups.