Borderline personality features and development of psychosis in an Ultra High Risk (UHR) population: a case control study
Early Intervention in Psychiatry, 06/08/2012
Thompson A et al. – Co–occurring borderline personality disorder (BPD) or BPD features does not appear to strongly influence the risk of short–term transition to psychosis or the risk of developing a non–affective psychotic disorder in this population.Methods
- This is a case-control study of ‘Ultra High Risk’ (UHR) for psychosis patients treated at the clinic, between 2004 and 2007.
- ‘Cases’ were UHR individuals who made the ‘transition’ to full threshold psychotic disorder within 24 months; ‘Control’ group was a matched UHR sample who had not developed a psychotic disorder at 24 months.
- Individuals were matched on time of entry to the clinic, age and gender.
- Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) BPD features were assessed from clinical assessments using a structured instrument (Structured Clinical Interview for DSM-IV Axis II Disorder for BPD (SCID-II BPD) ).
- Psychosis diagnosis following transition was rated from the clinical files using the operational criteria in studies of psychotic illness (OPCRIT) computer algorithm.
- The number of BPD traits and number with full threshold BPD were compared in those who developed psychosis and those who did not.
- The authors analysed data from 48 cases and 48 controls.
- There was no statistically significant difference in the rate of transition to psychosis for those with baseline full-threshold BPD, compared with those without BPD.
- The number of BPD traits or number with full threshold BPD did not differ by psychosis diagnosis grouping.