Prenatal Methamphetamine Exposure and Childhood Behavior Problems at 3 and 5 Years of Age
Pediatrics,

LaGasse LL et al. – This first report of behavior problems in patients as young as 3 years associated with methamphetamine (MA) exposure identifies an important public health problem. Continued follow–up can inform the development of preventive intervention programs.

Methods
  • The Infant Development, Environment, and Lifestyle study, a prospective, longitudinal study of prenatal MA exposure and child outcome, enrolled subjects postpartum in Los Angeles, California; Honolulu, Hawaii; Des Moines, Iowa; and Tulsa, Oklahoma.
  • Prenatal exposure was determined by maternal self-report and/or meconium results.
  • Prenatal exposures to tobacco, alcohol, or marijuana occurred in both groups.
  • At ages 3 and 5 years, 330 children (166 exposed and 164 comparison) were assessed for behavior problems by using the caregiver report on the Child Behavior Checklist.
  • General linear mixed models were used to determine the effects of prenatal MA exposure, including heavy exposure, age, and the interaction of exposure and age on behavior problems with adjustment for other drugs of abuse and environmental risk factors.

Results
  • MA exposure was associated with increased emotional reactivity and anxious/depressed problems at both ages and externalizing and attention-deficit/hyperactivity disorder problems by age 5 years.
  • Heavy exposure was related to attention problems and withdrawn behavior at both ages.
  • There were no effects of MA on the internalizing or total behavior problems scales.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Psychiatry

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Psychiatry Articles

1 Zolpidem and the risk of Parkinson's disease: A nationwide population-based study Journal of Psychiatric Research, August 1, 2014    Clinical Article

2 Blood manganese levels in relation to comorbid behavioral and emotional problems in children with attention-deficit/hyperactivity disorder Psychiatry Research, November 4, 2014    Clinical Article

3 Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study International Journal of Epidemiology, November 18, 2014    Clinical Article

4 The influence of inflammatory cytokines in physiopathology of suicidal behavior Journal of Affective Disorders, November 5, 2014    Evidence Based Medicine    Review Article

5 Maternal use of selective serotonin reuptake inhibitors and risk of miscarriage - assessing potential biases Paediatric and Perinatal Epidemiology, November 12, 2014    Clinical Article

6 Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: A systematic review and meta-analysis of randomized clinical trials JAMA Psychiatry, October 22, 2014    Evidence Based Medicine    Clinical Article

7 Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: A systematic review and meta-analysis Journal of Child Psychology and Psychiatry, November 19, 2014    Evidence Based Medicine

8 Investigation of the Montreal Cognitive Assessment (MoCA) as a cognitive screener in severe mental illness Psychiatry Research, November 10, 2014    Clinical Article

9 Is depression associated with increased oxidative stress?: A systematic review and meta-analysis Psychoneuroendocrinology, November 7, 2014    Evidence Based Medicine

10 Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations Psychoneuroendocrinology, November 6, 2014    Clinical Article

11 Serum dehydroepiandrosterone sulfate and incident depression in the elderly: The Pro.V.A Study The American Journal of Geriatric Psychiatry, November 24, 2014    Clinical Article

12 Effects of perinatal mental disorders on the fetus and child The Lancet, November 21, 2014    Evidence Based Medicine    Clinical Article

13 Antidepressant–induced sexual dysfunction during treatment with fluoxetine, sertraline, and trazodone: A randomized controlled trial General Hospital Psychiatry, November 7, 2014    Clinical Article

14 The serotonin-N-acetylserotonin–melatonin pathway as a biomarker for autism spectrum disorders Full Text Translational Psychiatry, November 26, 2014    Free full text    Clinical Article

15 Bipolar disorder, affective psychosis, and schizophrenia in pregnancy and the post-partum period The Lancet, November 20, 2014    Evidence Based Medicine

16 Comparative efficacy and acceptability of drug treatments for bipolar depression: A multiple-treatments meta-analysis Acta Psychiatrica Scandinavica, October 10, 2014    Evidence Based Medicine    Clinical Article

17 Behavioral activation therapy for return to work in medication-responsive chronic depression with persistent psychosocial dysfunction Comprehensive Psychiatry, November 13, 2014    Clinical Article

18 Specific and common genes implicated across major mental disorders: A review of meta-analysis studies Journal of Psychiatric Research, November 17, 2014    Review Article

19 Association between toll-like receptors expression and major depressive disorder Psychiatry Research, November 11, 2014    Clinical Article

20 The effect of bupropion XL and escitalopram on memory and functional outcomes in adults with major depressive disorder: Results from a randomized controlled trial Psychiatry Research, November 4, 2014    Clinical Article

Indexed Journals in Psychiatry : Current Psychiatry, Bipolar Disorders, American Journal of Psychiatry, Addictionmore