A history of depression in women is associated with an altered GABAergic neuroactive steroid profile

Psychoneuroendocrinology, 02/24/2012

Results indicated that both before and after oral progesterone, women with histories of depression showed lower concentrations of all GABAergic neuroactive steroids than never depressed women. Those with a history of depression also had lower cortisol concentrations. Because serum neuroactive steroids are mainly synthesized in the adrenals, the authors hypothesize that histories of depression may be associated with persistent adrenal suppression.

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