Body mass index increase, serum leptin, adiponectin, neuropeptide Y and lipid levels during treatment with olanzapine and haloperidol
Pharmacopsychiatry, 08/18/2011
Clinical Article
Raposo NRB et al. – Antipsychotics probably interfere on leptin and NPY signalling ways and disturb these hormones in eating behaviour control.
Methods- 9-month, randomized and naturalist study
- 34 male patients, 18 on olanzapine and 16 on haloperidol were enrolled
- All patients under monotherapy
- Patient outcome evaluated with positive and negative syndrome scale (PANSS) at every 3-month period
- In each visit, BMI, leptin, NPY, lipid, olanzapine or haloperidol levels monitored
- Leptin levels positively correlated with BMI in olanzapine (r=0.64, p<0.001) and haloperidol (r=0.73, p<0.001) groups; only in olanzapine patients, former also correlated with PANSS score (r=0.54, p<0.05)
- NPY levels negatively correlated with olanzapine levels (r= -0.65, p<0.01)
- Adiponectin levels had not significantly varied
