Maternal Cannabis Use Alters Ventral Striatal Dopamine D2 Gene Regulation in the Offspring
Biological Psychiatry,

DiNieri JA et al. – These data suggest that maternal cannabis use alters developmental regulation of mesolimbic D2R in offspring through epigenetic mechanisms that regulate histone lysine methylation, and the ensuing reduction of D2R might contribute to addiction vulnerability later in life.

Methods
  • Striatal dopamine and opioid–related genes were studied in human fetal subjects exposed to cannabis (as well as cigarettes and alcohol).
  • Cannabis–related gene disturbances observed in the human fetus were subsequently characterized with model of prenatal delta–9–tetrahydrocannabinol (THC) (.15 mg/kg) exposure.

Results
  • Prenatal cannabis exposure decreased dopamine receptor D2 (DRD2) messenger RNA expression in the human ventral striatum (nucleus accumbens [NAc]), a key brain reward region.
  • No significant alterations were observed for the other genes in cannabis–exposed subjects.
  • Maternal cigarette use was associated with reduced NAc prodynorphin messenger RNA expression, and alcohol exposure induced broad alterations primarily in the dorsal striatum of most genes.
  • To explore the mechanisms underlying the cannabis–associated disturbances, they exposed pregnant rats to THC and examined the epigenetic regulation of the NAc Drd2 gene in their offspring at postnatal day 2, comparable to the human fetal period studied, and in adulthood.
  • Chromatin immunoprecipitation of the adult NAc revealed increased 2meH3K9 repressive mark and decreased 3meH3K4 and RNA polymerase II at the Drd2 gene locus in the THC–exposed offspring.
  • Decreased Drd2 expression was accompanied by reduced dopamine D2 receptor (D2R) binding sites and increased sensitivity to opiate reward in adulthood.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Psychiatry

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Psychiatry Articles

1 Zolpidem and the risk of Parkinson's disease: A nationwide population-based study Journal of Psychiatric Research, August 1, 2014    Clinical Article

2 Blood manganese levels in relation to comorbid behavioral and emotional problems in children with attention-deficit/hyperactivity disorder Psychiatry Research, November 4, 2014    Clinical Article

3 Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study International Journal of Epidemiology, November 18, 2014    Clinical Article

4 The influence of inflammatory cytokines in physiopathology of suicidal behavior Journal of Affective Disorders, November 5, 2014    Evidence Based Medicine    Review Article

5 Maternal use of selective serotonin reuptake inhibitors and risk of miscarriage - assessing potential biases Paediatric and Perinatal Epidemiology, November 12, 2014    Clinical Article

6 Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: A systematic review and meta-analysis of randomized clinical trials JAMA Psychiatry, October 22, 2014    Evidence Based Medicine    Clinical Article

7 Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: A systematic review and meta-analysis Journal of Child Psychology and Psychiatry, November 19, 2014    Evidence Based Medicine

8 Investigation of the Montreal Cognitive Assessment (MoCA) as a cognitive screener in severe mental illness Psychiatry Research, November 10, 2014    Clinical Article

9 Is depression associated with increased oxidative stress?: A systematic review and meta-analysis Psychoneuroendocrinology, November 7, 2014    Evidence Based Medicine

10 Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations Psychoneuroendocrinology, November 6, 2014    Clinical Article

11 Serum dehydroepiandrosterone sulfate and incident depression in the elderly: The Pro.V.A Study The American Journal of Geriatric Psychiatry, November 24, 2014    Clinical Article

12 Effects of perinatal mental disorders on the fetus and child The Lancet, November 21, 2014    Evidence Based Medicine    Clinical Article

13 Antidepressant–induced sexual dysfunction during treatment with fluoxetine, sertraline, and trazodone: A randomized controlled trial General Hospital Psychiatry, November 7, 2014    Clinical Article

14 The serotonin-N-acetylserotonin–melatonin pathway as a biomarker for autism spectrum disorders Full Text Translational Psychiatry, November 26, 2014    Free full text    Clinical Article

15 Bipolar disorder, affective psychosis, and schizophrenia in pregnancy and the post-partum period The Lancet, November 20, 2014    Evidence Based Medicine

16 Comparative efficacy and acceptability of drug treatments for bipolar depression: A multiple-treatments meta-analysis Acta Psychiatrica Scandinavica, October 10, 2014    Evidence Based Medicine    Clinical Article

17 Behavioral activation therapy for return to work in medication-responsive chronic depression with persistent psychosocial dysfunction Comprehensive Psychiatry, November 13, 2014    Clinical Article

18 Specific and common genes implicated across major mental disorders: A review of meta-analysis studies Journal of Psychiatric Research, November 17, 2014    Review Article

19 Association between toll-like receptors expression and major depressive disorder Psychiatry Research, November 11, 2014    Clinical Article

20 The effect of bupropion XL and escitalopram on memory and functional outcomes in adults with major depressive disorder: Results from a randomized controlled trial Psychiatry Research, November 4, 2014    Clinical Article

Indexed Journals in Psychiatry : Current Psychiatry, Bipolar Disorders, American Journal of Psychiatry, Addictionmore