Methylphenidate Effects on Prefrontal Functioning During Attentional-Capture and Response Inhibition
Biological Psychiatry, 05/11/2012Pauls AM et al.
The findings suggest that the improvement of response inhibition seen following methylphenidate administration is due to its influence on underlying attentional mechanisms linked to response control requirements.
The effects of methylphenidate (40 mg) were assessed using functional magnetic resonance imaging in 16 healthy volunteers in a within-subject, double-blind, placebo-controlled design.
Methylphenidate significantly reduced activation of different regions within the right inferior frontal gyrus/insula to infrequent stimuli associated with successful inhibition, failed inhibition, and attentional capture.
These inferior frontal gyrus regions showed different interregional connections with inhibitory and attention networks.
For failed inhibitions, methylphenidate increased activation within performance-monitoring regions, including the superior frontal, anterior cingulate, and parietal-occipital cortices, but only after controlling for attentional capture.
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