Myocardial infarction and generalised anxiety disorder: 10-year follow-up

The British Journal of Psychiatry, 04/04/2012

Generalised anxiety disorder was associated with an almost twofold increased risk of adverse outcomes independent demographic and clinical variables and depression.


  • Patients with acute myocardial infarction (n = 438) were recruited between 1997 and 2000 and were followed up until 2007.
  • Current generalised anxiety disorder and post-myocardial infarction depression were assessed with the Composite International Diagnostic Interview.
  • The end-point consisted of all-cause mortality and cardiovascular-related readmissions.


  • During the follow-up period, 198 patients had an adverse event.
  • Generalised anxiety disorder was associated with an increased rate of adverse events after adjustment for age and gender (hazard ratio: 1.94; 95% confidence interval: 1.14-3.30; P = 0.01).
  • Additional adjustment for measures of cardiac disease severity and depression did not change the results.

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