Smoking, Smoking Cessation, and Disease Activity in a Large Cohort of Patients with Rheumatoid Arthritis

The Journal of Rheumatology, 04/02/2012

Fisher MC et al. – In the short term, smoking cessation did not appear to influence change in disease activity over time.


  • Patients enrolled in the Consortium of Rheumatology Researchers of North America registry (CORRONA) were stratified into never, former, and current smokers at enrollment.
  • Current smokers were further stratified into continued and ceased smoking groups during their followup in the registry.
  • The primary outcome was change in Clinical Disease Activity Index (CDAI) at last visit in a multivariate, random–effects regression model accounting for multiple timepoints.


  • At last visit, there was no significant change in CDAI between ceased smokers and continued smokers (coefficient –0.00091, SE 0.0033, p = 0.7834).
  • The study did confirm prior cross–sectional studies that current smokers have worse disease activity than former or never smokers.

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