Effects of acamprosate on cognition in a treatment study of patients with schizophrenia spectrum disorders and comorbid alcohol dependence

The Journal of Nervous and Mental Disease, 07/11/2011

Ralevski E et al. – The objectives of this study were to examine the effect of acamprosate treatment on cognition and to assess whether the changes in drinking patterns or psychotic symptoms were related to changes in cognitive functioning.


  • 23 Outpatients with schizophrenia spectrum disorders and alcohol dependence
  • Randomized (double-blind) to either acamprosate or placebo treatment for 12 weeks
  • Assessments (baseline and week 12) included alcohol use, symptoms of psychosis, memory, and attention


  • Results showed that acamprosate had no effect on cognitive functioning
  • No relationship between change in alcohol consumption or psychotic symptoms and change in cognitive functioning in this sample of patients

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