Lifetime History of Depression and Anxiety Disorders as a Predictor of Quality of Life in Midlife Women in the Absence of Current Illness Episodes JAMA Psychiatry, 05/15/2012

Joffe H et al. – A history of both depression and anxiety has the most robust negative effect on health–related quality of life (HRQOL) in women during midlife, an association not explained by vasomotor symptoms or sleep disturbance. For the depression–alone group, sleep disturbance may partially explain the negative impact of previous affective illness on HRQOL. Sleep disturbance remains an independent correlate of low HRQOL.

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