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HMGB1 in Renal Ischemic Injury
American Journal of Physiology: Renal Physiology, 07/11/2012

Rabadi MM et al. – The authors' results indicate that increased ischemic duration causes progressively enhanced HMGB1 release into the circulation triggering damage/repair signaling, an effect inhibited by ethyl pyruvate because of its ability to block HMGB1 nuclear–cytoplasmic translocation.

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