Hyponatremia in a patient with scleroderma renal crisis: a potential role of activated renin-angiotensin system
BMC Nephrology, 06/29/2012

Fukasawa H et al. – A 66–year–old man with scleroderma was admitted to the authors' hospital for an evaluation of renal dysfunction and extreme hypertension. The laboratory evaluation revealed remarkably high plasma renin activity in association with microangiopathic hemolytic anemia, and the anti– RNA polymerase III antibody assessment was positive. The patient was diagnosed with scleroderma renal crisis and was started treatment with enalapril maleate, an angiotensinconverting enzyme inhibitor. To the authors' best knowledge, this is the first documented case of scleroderma renal crisis complicated with hyponatremia. This report also suggests that the activated renin–angiotensin system may play a role in the development of hyponatremia and that hyponatremia should be taken into consideration as a rare but possible complication associated with screloderma renal crisis.