Physician Assistant - Clinical Pharmacology News & Articles

The Medical Editors at MDLinx.com diligently work around the clock to provide the most current Physician Assistant medical news articles from over 2,000 peer-reviewed clinical journals. Our coverage includes over 32 specialties and 800 subspecialties, perfect for the multidisciplinary practice of today’s PAs. Topics include: everything from Anesthesiology to Women’s Health, plus Economics of Medicine, Popular Press, Teaching Hospital News, and much more. In less than 5 minutes a day, Physician Assistants can be updated with the latest published information from thousands of journals after consulting just one resource.

Read on to find exclusive content highly recommended by our Senior Editor, D. Scott Cunningham, MD, PhD, along with clinical pearls from the Smartest Doc , a daily quiz competition now available in 10 specialties.

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Latest (11) Full Text Articles (899)

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121 Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus Full Text BMC Pharmacology & Toxicology, May 9, 2013    Clinical Article

122 Effects of rosuvastatin versus atorvastatin on small dense low-density lipoprotein: a meta-analysis of randomized trials Heart and Vessels, May 8, 2013    Evidence Based Medicine    Review Article    Clinical Article

123 Comparative safety and effectiveness of sitagliptin in patients with type 2 diabetes: retrospective population based cohort study British Medical Journal, May 8, 2013    Evidence Based Medicine    Clinical Article

124 Aspirin: Its risks, benefits, and optimal use in preventing cardiovascular events Full Text Cleveland Clinic Journal of Medicine, May 8, 2013    Clinical Article

125 B-Cell Depletion With Rituximab in Patients With Primary Biliary Cirrhosis Refractory to Ursodeoxycholic Acid The American Journal of Gastroenterology, May 8, 2013    Clinical Article

126 Clinical characteristics and effectiveness of lansoprazole in Japanese patients with gastroesophageal reflux disease and dyspepsia Journal of Gastroenterology, May 8, 2013    Clinical Article

127 Long-term follow-up of the FL2000 study comparing CHVP-interferon to CHVP-interferon plus rituximab in follicular lymphoma Full Text Haematologica, May 8, 2013    Clinical Article

128 Reactive Increase in Gastric Mucus Secretion Is an Adaptive Defense Mechanism Against Low-Dose Aspirin-Induced Gastropathy Digestive Diseases and Sciences, May 8, 2013    Clinical Article

129 Impact of diabetes on treatment outcomes and long-term survival in multidrug-resistant tuberculosis Respiration, May 8, 2013    Clinical Article

130 A randomised controlled trial of financial incentives to increase hepatitis B vaccination completion among people who inject drugs in Australia Preventive Medicine, May 8, 2013    Clinical Article

131 Lack of a Pharmacokinetic Interaction Between Treprostinil Diolamine and Sildenafil in Healthy Adult Volunteers Journal of Cardiovascular Pharmacology, May 8, 2013    Clinical Article

132 Switch from selegiline to rasagiline is beneficial in patients with Parkinsons disease Journal of Neural Transmission, May 8, 2013    Clinical Article

133 Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A2A antagonism European Journal of Neuroscience, May 8, 2013    Review Article

134 Elevated PCSK9 Levels in Untreated Patients With Heterozygous or Homozygous Familial Hypercholesterolemia and the Response to High-Dose Statin Therapy Full Text Journal of the American Heart Association, May 8, 2013    Clinical Article

135 Evaluation of Type 2 Diabetes Mellitus Medication Management and Control in Older Adults The Consultant Pharmacist, May 8, 2013    Clinical Article

136 Adherence Associated with Oral Medications in the Treatment of Spasticity PM&R, May 8, 2013    Clinical Article

137 Usefulness of omalizumab in ten patients with severe occupational asthma Allergy, May 7, 2013    Clinical Article

138 Real-life comparison of beclometasone dipropionate as an extrafine- or larger-particle formulation for asthma Respiratory Medicine, May 7, 2013    Clinical Article

139 Clinical effects of adalimumab treatment with concomitant azathioprine in Japanese Crohn’s disease patients Full Text World Journal of Gastroenterology, May 7, 2013    Clinical Article

140 Patterns of Warfarin Use in Subgroups of Patients with Atrial Fibrillation: A Cross-Sectional Analysis of 430 General Practices in the United Kingdom PLOS ONE, May 7, 2013    Evidence Based Medicine    Clinical Article

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Clinical Pearls in Physician Assistant

Smoking increases the risk of both acute myocardial infarction and unstable angina pectoris more than alcohol consumption and physical activity, independent of family history

Rectal bleeding, anemia, especially iron-deficiency anemia, weight loss, nocturnal symptoms, and family history of sprue, colorectal cancer, or inflammatory bowel disorder are alarm signals in patients with suspected irritable bowel syndrome.

Psychological interventions to promote adjustment in children with CHD benefit family functioning

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Highlights in Physician Assistant

Statins do not increase risk of malignant melanoma in postmenopausal women

In a study headed by researchers at Wayne State University involving 119,726 postmenopausal women enrolled in the Women’s Health Initiative, there were 1099 incident cases of malignant melanoma over an average follow-up of 11.6 y. At the time of enrollment, 7.4% of the participants used statins. The annualized rate of malignant melanoma in the statin users and non-users was 0.09% (HR=1.14). Thus, statin use does not increase the risk of malignant melanoma in postmenopausal women.
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Simple, safe, effective, low-cost treatment for cancer-related anorexia/cachexia syndrome

A phase III trial conducted at the University of Cagliari showed that either of two regimens were effective in the treatment of cancer-related anorexia/cachexia syndrome (CACS). Sixty patients were randomized to receive one of the following treatment interventions for 4 months: 1) L-carnitine (4 g/d) + celecoxib (300 mg/d); or 2) L-carnitine + celecoxib + megestrol acetate (320 mg/d). All patients also received polyphenols (300 mg/d), lipoic acid (300 mg/d), carbocysteine (2.7 g/d), and vitamins A, C, and E. Lean body mass (dual energy X-ray absorptiometry and L3 computed tomography) and physical activity (6-min walk test) increased in both groups.
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HPA axis, metabolic impairment, and pediatric obesity

As published in BMC Medicine, elevated ACTH levels are associated with hypertriglyceridemia and hyperglycemia, and elevated cortisol levels are associated with hypertension and high LDL-C in obese children and adolescents (n=450).
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Most Popular Physician Assistant Articles
Last month's top read Top Articles of 2012

1 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013    Free full text

2 Statins and autoimmunity Immunologic Research, April 17, 2013    Review Article

3 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

4 Omega-3 in Antiarrhythmic Therapy High Blood Pressure & Cardiovascular Prevention, April 16, 2013

5 Leukaemia update. Part 1: diagnosis and management British Medical Journal, April 9, 2013    Review Article

Indexed Journals in Physician Assistant: Advance for Physicians Assistants, American Family Physician more

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