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Physician Assistant - Clinical Pharmacology News & Articles

The Medical Editors at MDLinx.com diligently work around the clock to provide the most current Physician Assistant medical news articles from over 2,000 peer-reviewed clinical journals. Our coverage includes over 32 specialties and 800 subspecialties, perfect for the multidisciplinary practice of today’s PAs. Topics include: everything from Anesthesiology to Women’s Health, plus Economics of Medicine, Popular Press, Teaching Hospital News, and much more. In less than 5 minutes a day, Physician Assistants can be updated with the latest published information from thousands of journals after consulting just one resource.

Read on to find exclusive content highly recommended by our Senior Editor, D. Scott Cunningham, MD, PhD, along with clinical pearls from the Smartest Doc , a daily quiz competition now available in 10 specialties.

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Latest (15) Full Text Articles (899)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
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21 Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma Hepatology, May 23, 2013    Clinical Article

22 Three times weekly glatiramer acetate in relapsing-remitting multiple sclerosis Annals of Neurology , May 23, 2013    Clinical Article

23 Sustained clinical benefit and tolerability of methotrexate monotherapy after thiopurine therapy in patients with crohns disease Clinical Gastroenterology and Hepatology , May 23, 2013    Clinical Article

24 Intragastric acidity and omeprazole exposure during dosing with either PA32540 (enteric-coated aspirin 325 mg + immediate-release omeprazole 40 mg) or enteric-coated aspirin 325 mg + enteric-coated omeprazole 40 mg – a randomised, phase 1, crossover study Alimentary Pharmacology and Therapeutics, May 23, 2013    Clinical Article

25 Efficacy and safety of carisbamate in patients with diabetic neuropathy or postherpetic neuralgia: results from 3 randomized, double-blind placebo-controlled trials Pain Practice, May 23, 2013    Clinical Article

26 Blood pressure-lowering effect of simvastatin: a placebo-controlled randomized clinical trial with 24-h ambulatory blood pressure monitoring Journal of Human Hypertension, May 23, 2013    Clinical Article

27 Effect of addition of clopidogrel to aspirin on stroke incidence: Meta-analysis of randomized trials International Journal of Stroke, May 23, 2013    Clinical Article

28 The place of medical treatment of acromegaly: current status and perspectives Expert Opinion on Pharmacotherapy, May 23, 2013    Review Article

29 Cost-Utility Analysis of the Inhaled Steroids Available in a Developing Country for the Management of Pediatric Patients with Persistent Asthma Journal of Asthma, May 23, 2013    Clinical Article

30 Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome Full Text BMC Nephrology, May 23, 2013    Clinical Article

31 Addressing the questions of tomorrow: melphalan and new combinations as conditioning regimens before autologous hematopoietic progenitor cell transplantation in multiple myeloma Expert Opinion on Investigational Drugs, May 23, 2013    Review Article

32 Adverse cardiovascular outcomes associated with concurrent use of clopidogrel or ticlopidine and proton-pump inhibitors in patients undergoing percutaneous coronary intervention Heart and Vessels, May 23, 2013    Clinical Article

33 Gynura procumbens Causes Vasodilation by Inhibiting Angiotensin II and Enhancing Bradykinin Actions Journal of Cardiovascular Pharmacology, May 23, 2013    Clinical Article

34 Assessment of drug use pattern using WHO prescribing indicators at Hawassa University teaching and referral hospital, south Ethiopia: a cross-sectional study Full Text BMC Health Services Research, May 23, 2013    Clinical Article

35 Effects of beraprost sodium on subjective symptoms in diabetic patients with peripheral arterial disease Full Text Clinics in Orthopedic Surgery, May 23, 2013    Clinical Article

36 Ibrutinib: an evidence-based review of its potential in the treatment of advanced chronic lymphocytic leukemia Core Evidence, May 23, 2013    Clinical Article

37 Comparison of Effects of Serum n-3 to n-6 Polyunsaturated Fatty Acid Ratios on Coronary Atherosclerosis in Patients Treated With Pitavastatin or Pravastatin Undergoing Percutaneous Coronary Intervention The American Journal of Cardiology, May 22, 2013    Clinical Article

38 Efficacy and safety of Privigen in patients with chronic inflammatory demyelinating polyneuropathy: results of a prospective, single-arm, open-label Phase III study (the PRIMA study) Journal of the Peripheral Nervous System, May 22, 2013    Clinical Article

39 Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine clinical practice Gut, May 22, 2013    Clinical Article
Exclusive Author Commentary

40 Heart failure in patients treated with bisphosphonates Journal of Internal Medicine, May 22, 2013    Evidence Based Medicine    Clinical Article

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Clinical Pearls in Physician Assistant

Highlights in Physician Assistant

Statins do not increase risk of malignant melanoma in postmenopausal women

In a study headed by researchers at Wayne State University involving 119,726 postmenopausal women enrolled in the Women’s Health Initiative, there were 1099 incident cases of malignant melanoma over an average follow-up of 11.6 y. At the time of enrollment, 7.4% of the participants used statins. The annualized rate of malignant melanoma in the statin users and non-users was 0.09% (HR=1.14). Thus, statin use does not increase the risk of malignant melanoma in postmenopausal women.

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Simple, safe, effective, low-cost treatment for cancer-related anorexia/cachexia syndrome

A phase III trial conducted at the University of Cagliari showed that either of two regimens were effective in the treatment of cancer-related anorexia/cachexia syndrome (CACS). Sixty patients were randomized to receive one of the following treatment interventions for 4 months: 1) L-carnitine (4 g/d) + celecoxib (300 mg/d); or 2) L-carnitine + celecoxib + megestrol acetate (320 mg/d). All patients also received polyphenols (300 mg/d), lipoic acid (300 mg/d), carbocysteine (2.7 g/d), and vitamins A, C, and E. Lean body mass (dual energy X-ray absorptiometry and L3 computed tomography) and physical activity (6-min walk test) increased in both groups.

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HPA axis, metabolic impairment, and pediatric obesity

As published in BMC Medicine, elevated ACTH levels are associated with hypertriglyceridemia and hyperglycemia, and elevated cortisol levels are associated with hypertension and high LDL-C in obese children and adolescents (n=450).

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