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Physician Assistant - Clinical Pharmacology News & Articles

The Medical Editors at MDLinx.com diligently work around the clock to provide the most current Physician Assistant medical news articles from over 2,000 peer-reviewed clinical journals. Our coverage includes over 32 specialties and 800 subspecialties, perfect for the multidisciplinary practice of today’s PAs. Topics include: everything from Anesthesiology to Women’s Health, plus Economics of Medicine, Popular Press, Teaching Hospital News, and much more. In less than 5 minutes a day, Physician Assistants can be updated with the latest published information from thousands of journals after consulting just one resource.

Read on to find exclusive content highly recommended by our Senior Editor, D. Scott Cunningham, MD, PhD, along with clinical pearls from the Smartest Doc , a daily quiz competition now available in 10 specialties.

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Latest (21) Full Text Articles (899)
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

181 Comparative Effectiveness of Early Natalizumab Treatment in JC Virus'Negative Relapsing-Remitting Multiple Sclerosis Full Text The American Journal of Managed Care, May 6, 2013    Review Article

182 Autocrine motility factor injection for motor plate regeneration and muscle function restoration--a pilot study Acta Neurochirurgica, May 6, 2013    Clinical Article

183 When ‘digoxin use’ is not the same as ‘digoxin use’: lessons from the AFFIRM trial European Heart Journal, May 3, 2013    Clinical Article

184 A Pilot Study Identifying Statin Nonadherence With Visit-to-Visit Variability of Low-Density Lipoprotein Cholesterol The American Journal of Cardiology, May 3, 2013    Clinical Article

185 Quinidine, a life-saving medication for Brugada syndrome, is inaccessible in many countries JACC - Journal of the American College of Cardiology, May 3, 2013    Clinical Article

186 Hemorrhagic and Ischemic Outcomes After Bivalirudin Versus Unfractionated Heparin During Carotid Artery Stenting Circulation: Cardiovascular Interventions, May 3, 2013    Clinical Article

187 Non-steroidal anti-inflammatory drug hypersensitivity in adults and the factors associated with asthma Respiratory Medicine, May 3, 2013    Clinical Article

188 Seizures and antiepileptic drugs in patients with spontaneous intracerebral hemorrhages Seizure - European Journal of Epilepsy, May 3, 2013    Clinical Article

189 The quest for rational antiepileptic polytherapy with supraadditive anticonvulsant efficacy Epilepsy & Behavior, May 3, 2013    Review Article

190 The Correlation Between Dose of Folinic Acid and Neurotoxicity in Children and Adolescents Treated for Osteosarcoma With High-dose Methotrexate (HDMTX): A Neuropsychological and Psychosocial Study Journal of Pediatric Hematology/Oncology, May 3, 2013    Clinical Article

191 Tolerability of diclofenac sodium 1% gel with concomitant medications known to interact with diclofenac Full Text Therapeutics and Clinical Risk Management, May 3, 2013    Clinical Article

192 Bioequivalence evaluation of epinephrine autoinjectors with attention to rapid delivery Full Text Therapeutics and Clinical Risk Management, May 3, 2013

193 Infliximab salvage therapy for patients with ulcerative colitis who failed to respond to tacrolimus European Journal of Gastroenterology & Hepatology, May 3, 2013    Clinical Article

194 Enterococcus faecalis Infective Endocarditis Circulation, May 2, 2013    Clinical Article

195 A phase 3, double-blind, randomised, parallel-group, placebo-controlled study of oral weekly alendronate for the prevention of androgen deprivation bone loss in nonmetastatic prostate cancer: the cancer and osteoporosis research with alendronate and leuprolide (coral) study Full Text European Urology, May 2, 2013    Clinical Article

196 Statin use in relation to prostate cancer outcomes in a population-based patient cohort study The Prostate, May 2, 2013    Clinical Article

197 Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non–ST-segment elevation acute coronary syndrome: Validity, pitfalls, and future approaches American Heart Journal, May 2, 2013    Clinical Article

198 Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors Clinical Cancer Research, May 2, 2013    Clinical Article

199 Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK British Journal of Cancer, May 2, 2013    Clinical Article

200 Understanding the Determinants of Antimicrobial Prescribing within hospitals: The role of Prescribing Etiquette Clinical Infectious Diseases, May 2, 2013    Review Article

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Clinical Pearls in Physician Assistant

Highlights in Physician Assistant

Statins do not increase risk of malignant melanoma in postmenopausal women

In a study headed by researchers at Wayne State University involving 119,726 postmenopausal women enrolled in the Women’s Health Initiative, there were 1099 incident cases of malignant melanoma over an average follow-up of 11.6 y. At the time of enrollment, 7.4% of the participants used statins. The annualized rate of malignant melanoma in the statin users and non-users was 0.09% (HR=1.14). Thus, statin use does not increase the risk of malignant melanoma in postmenopausal women.

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Simple, safe, effective, low-cost treatment for cancer-related anorexia/cachexia syndrome

A phase III trial conducted at the University of Cagliari showed that either of two regimens were effective in the treatment of cancer-related anorexia/cachexia syndrome (CACS). Sixty patients were randomized to receive one of the following treatment interventions for 4 months: 1) L-carnitine (4 g/d) + celecoxib (300 mg/d); or 2) L-carnitine + celecoxib + megestrol acetate (320 mg/d). All patients also received polyphenols (300 mg/d), lipoic acid (300 mg/d), carbocysteine (2.7 g/d), and vitamins A, C, and E. Lean body mass (dual energy X-ray absorptiometry and L3 computed tomography) and physical activity (6-min walk test) increased in both groups.

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HPA axis, metabolic impairment, and pediatric obesity

As published in BMC Medicine, elevated ACTH levels are associated with hypertriglyceridemia and hyperglycemia, and elevated cortisol levels are associated with hypertension and high LDL-C in obese children and adolescents (n=450).

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