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Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

1 Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration The Lancet, July 22, 2014    Evidence Based Medicine    Clinical Article

2 Early decrease in carotid plaque lipid content as assessed by magnetic resonance imaging during treatment of rosuvastatin Full Text BMC Cardiovascular Disorders, July 22, 2014    Clinical Article

3 Maximising the effect of combination HIV prevention through prioritisation of the people and places in greatest need: a modelling study The Lancet, July 22, 2014    Evidence Based Medicine    Clinical Article

4 Treatment discontinuations with new oral agents for long-term anticoagulation: insights from a meta-analysis of 18 randomized trials including 101,801 patients Mayo Clinic Proceedings, July 22, 2014    Evidence Based Medicine    Clinical Article

5 Simulated application of US cardiology guidelines for statin use to hospital patients in Turkey Quality Management in Health Care , July 22, 2014    Clinical Article

6 Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: outcomes from the CONKO-003 trial Journal of Clinical Oncology, July 22, 2014    Clinical Article

7 Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation report of 2 cases Annals of Internal Medicine, July 22, 2014    Clinical Article

8 Consuming a buttermilk drink containing lutein-enriched egg yolk daily for 1 year increased plasma lutein but did not affect serum lipid or lipoprotein concentrations in adults with early signs of age-related macular degeneration The Journal of Nutrition, July 22, 2014    Clinical Article

9 High fat diets are associated with higher abdominal adiposity regardless of physical activity in adolescents; the HELENA study Clinical Nutrition, July 22, 2014    Clinical Article

10 Cancer treatment disparities in HIV-infected individuals in the United States Journal of Clinical Oncology, July 22, 2014    Clinical Article

11 The effects of co-administration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: A randomized double-blind controlled clinical trial Clinical Nutrition, July 22, 2014    Clinical Article

12 Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: A case control study Clinical Nutrition, July 22, 2014    Clinical Article

13 Combined chemoradiotherapy with gemcitabine in patients with locally advanced inoperable transitional cell carcinoma of the urinary bladder and/or in patients ineligible for surgery: a phase I trial Annals of Oncology, July 22, 2014    Clinical Article

14 Serum albumin and kidney function decline in HIV-infected women American Journal of Kidney Diseases, July 22, 2014    Clinical Article

15 High-performance information search filters for CKD content in PubMed, Ovid MEDLINE, and EMBASE American Journal of Kidney Diseases, July 22, 2014    Clinical Article

16 Hemoglobin A in nondiabetic patients: an independent predictor of coronary artery disease and its severity Mayo Clinic Proceedings, July 22, 2014    Evidence Based Medicine    Clinical Article

17 Two different doses of supplemental vitamin a did not affect mortality of normal-birth-weight neonates in guinea-bissau in a randomized controlled trial The Journal of Nutrition, July 22, 2014    Clinical Article

18 Prognostic value of troponins in acute coronary syndrome depends upon patient age Heart, July 22, 2014    Clinical Article

19 The human response to acute enteral and parenteral phosphate loads Journal of the American Society of Nephrology, July 22, 2014    Clinical Article

20 Cardiac and kidney markers for cardiovascular prediction in individuals with chronic kidney disease Arteriosclerosis, Thrombosis, and Vascular Biology, July 22, 2014    Clinical Article

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Highlights in Physician Assistant

Statins do not increase risk of malignant melanoma in postmenopausal women

In a study headed by researchers at Wayne State University involving 119,726 postmenopausal women enrolled in the Women’s Health Initiative, there were 1099 incident cases of malignant melanoma over an average follow-up of 11.6 y. At the time of enrollment, 7.4% of the participants used statins. The annualized rate of malignant melanoma in the statin users and non-users was 0.09% (HR=1.14). Thus, statin use does not increase the risk of malignant melanoma in postmenopausal women.

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Simple, safe, effective, low-cost treatment for cancer-related anorexia/cachexia syndrome

A phase III trial conducted at the University of Cagliari showed that either of two regimens were effective in the treatment of cancer-related anorexia/cachexia syndrome (CACS). Sixty patients were randomized to receive one of the following treatment interventions for 4 months: 1) L-carnitine (4 g/d) + celecoxib (300 mg/d); or 2) L-carnitine + celecoxib + megestrol acetate (320 mg/d). All patients also received polyphenols (300 mg/d), lipoic acid (300 mg/d), carbocysteine (2.7 g/d), and vitamins A, C, and E. Lean body mass (dual energy X-ray absorptiometry and L3 computed tomography) and physical activity (6-min walk test) increased in both groups.

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HPA axis, metabolic impairment, and pediatric obesity

As published in BMC Medicine, elevated ACTH levels are associated with hypertriglyceridemia and hyperglycemia, and elevated cortisol levels are associated with hypertension and high LDL-C in obese children and adolescents (n=450).

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