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1 Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial The Lancet, December 19, 2014 Evidence Based Medicine Clinical Article
2 Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): a randomised, open-label phase 2 trial The Lancet, December 19, 2014 Evidence Based Medicine Clinical Article
3 Effect of neonatal vitamin A supplementation on mortality in infants in Tanzania (Neovita): a randomised, double-blind, placebo-controlled trial The Lancet, December 19, 2014 Evidence Based Medicine Clinical Article
4 Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial The Lancet, December 19, 2014 Evidence Based Medicine Clinical Article
5 Low-dose aspirin for primary prevention of cardiovascular events in japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial JAMA, December 19, 2014 Evidence Based Medicine Clinical Article
6 Randomized phase II trial of gemcitabine plus TH-302 versus gemcitabine in patients with advanced pancreatic cancer Journal of Clinical Oncology, December 19, 2014 Clinical Article
7 PCSK 7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: The POUNDS lost trial Diabetes Care, December 19, 2014 Clinical Article
8 Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes Diabetes Care, December 19, 2014 Clinical Article
9 A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history Diabetes Care, December 19, 2014 Clinical Article
10 Hypoglycemia and risk of cardiovascular disease and all-cause mortality in insulin-treated people with type 1 and type 2 diabetes: a cohort study Diabetes Care, December 19, 2014 Clinical Article
11 Prevalence of detectable C-peptide according to age at diagnosis and duration of type 1 diabetes Diabetes Care, December 19, 2014 Clinical Article
12 Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors Diabetes Care, December 19, 2014 Clinical Article
13 The metabolic profile of intrahepatic cholestasis of pregnancy is associated with impaired glucose tolerance, dyslipidemia, and increased fetal growth Diabetes Care, December 19, 2014 Clinical Article
14 The effect of metformin on glucose homeostasis during moderate exercise Diabetes Care, December 19, 2014 Clinical Article
15 Impact of replacing smear microscopy with Xpert MTB/RIF for diagnosing tuberculosis in Brazil: A stepped-wedge cluster-randomized trial Full Text PLoS Medicine, December 19, 2014 Evidence Based Medicine Clinical Article
16 Multiple-band imaging provides better value than white-light endoscopy in detection of dysplasia in patients with Barrett's esophagus Clinical Gastroenterology and Hepatology , December 19, 2014 Clinical Article
17 Abdomino-thoracic mechanisms of functional abdominal distension and correction by biofeedback Gastroenterology, December 19, 2014 Clinical Article
18 Changing incidence and outcomes following dialysis-requiring acute kidney injury among critically ill adults: A population-based cohort study American Journal of Kidney Diseases, December 19, 2014 Clinical Article
19 Progressive resistance exercise training in CKD: A feasibility study American Journal of Kidney Diseases, December 19, 2014 Clinical Article
20 Mast cells promote T cell driven antigen-induced arthritis despite being dispensable in T cell bypassing antibody-induced arthritis Arthritis & Rheumatism, December 19, 2014 Clinical Article
As reported in PLoS ONE, the expression of PTPN12 was decreased in hepatocellular carcinoma tissue samples compared with adjacent normal tissues. Furthermore, decreased PTPN12 expression was associated with tumor recurrence, decreased cancer-specific survival, and decreased recurrence-free survival.
As reported in the British Journal of Cancer, patients with diabetes (n=62) are at increased risk of death from pancreatic cancer overall (HR=1.52) and within 3 years of diagnosis (HR=1.45).
As reported in the International Journal of Clinical Oncology, the 5-year biochemical recurrence (BCR)-free survival rate is significantly higher in patients with a 3-month PSA level < 0.010 ng/ml compared to patients with a 3-month PSA level between 0.010 and 100 ng/ml (92.6% vs. 57.4%). Amongst 174 men who underwent radical prostatectomy for clinically localized prostate cancer, 18.4% had a BCR and the median time to BCR was 16 months.