Intermittent ?-lactam bolus therapy less effective than prolonged infusion
Based on a meta-analysis (n=29 studies [2206 patients]) published in the Journal of Antimicrobial Agents, intermittent β-lactam therapy was less effective than prolonged infusion with respect to mortality rate (RR = 0.66) and clinical success (RR = 1.12).
Decreased PTPN12 expression associated with poor prognosis in HCC
As reported in PLoS ONE, the expression of PTPN12 was decreased in hepatocellular carcinoma tissue samples compared with adjacent normal tissues. Furthermore, decreased PTPN12 expression was associated with tumor recurrence, decreased cancer-specific survival, and decreased recurrence-free survival.
s-H-FABP levels predict outcome in ICU patients
As reported in Clinical Research in Cardiology, the level of serum heart-type fatty acid-binding protein (s-H-FABP) is higher in ER patients admitted to the ICU than ER patients admitted to other departments. The s-H-FABP level was also higher in ICU non-survivors than ICU survivors. A s-H-FABP level of 20.95 ng/ml had a 81.1% and 66.0% sensitivity and specificity, respectively, for in-hospital mortality.