We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Efficacy, safety, and immunogenicity of an oral recombinant vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trialThe Lancet, July 01, 2015  Clinical Article  Evidence Based Medicine
2Safety of infusing ipilimumab over 30 minutesJournal of Clinical Oncology, July 01, 2015  Clinical Article
3Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: retrospective analysis of the avaglio trialJournal of Clinical Oncology, July 01, 2015  Clinical Article
4Estimated global, regional, and national disease burdens related to sugar-sweetened beverage consumption in 2010Circulation, July 01, 2015  Clinical Article
5Cerebral small vessel disease and association with higher incidence of depressive symptoms in a general elderly population: The AGES-Reykjavik studyAmerican Journal of Psychiatry, July 01, 2015  Clinical Article
6Clarithromycin in γ-aminobutyric acid–Related hypersomnolence: A randomized, crossover trialAnnals of Neurology , July 01, 2015  Clinical Article
7Efficacy of a Chinese herbal medicine in providing adequate relief of constipation-predominant irritable bowel syndrome: A randomized controlled trialClinical Gastroenterology and Hepatology , July 01, 2015  Clinical Article
8Loss of ATOH8 increases stem cell features of hepatocellular carcinoma cellsGastroenterology, July 01, 2015  Clinical Article
9Early dialysis and adverse outcomes after Hurricane SandyAmerican Journal of Kidney Diseases, July 01, 2015  Clinical Article
10The inadmissibility of what we eat in America and nhanes dietary data in nutrition and obesity research and the scientific formulation of national dietary guidelinesMayo Clinic Proceedings, July 01, 2015  Review Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1First-ever possible treatments for Middle East Respiratory Syndrome; UMSOM researchers identify two promising candidates to prevent and treat deadly epidemicUniversity of Maryland School of Medicine News, July 01, 2015
2ACC council addresses cardiac arrest in non-STEMI patientsAmerican College of Cardiology News, July 01, 2015
3Lack of sanitation for 2.4 billion people is undermining health improvementsWHO news, July 01, 2015
4WHO validates elimination of mother-to-child transmission of HIV and syphilis in CubaWHO news, July 01, 2015
5Pitt leads trial to reduce antibiotic overuse at post-acute and long-term care facilitiesUPMC, July 01, 2015
6Paraplegic patients stand tall in motorized exoskeleton testUW Medicine, June 30, 2015
7Telehealth video consults to reach 158 million annually by 2020HIT Consultant , June 30, 2015
8Bedside Ebola diagnosticHarvard Medical School News, June 30, 2015
9Sleeping on the job? Actually, that's a good thingUniversity of Michigan Regents News, June 30, 2015
10Feeling impulsive or frustrated? Take a napUniversity of Michigan Regents News, June 30, 2015

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CTC count predicts survival in mBC

As reported in The Lancet Oncology, circulating tumor cell (CTC) quantification in patients (20 studies; n = 1944) with metastatic breast cancer (mBC) predicts progression-free survival (PFS) and overall survival (OS), especially when coupled with clinicopathologic data. A CTC count ≥ 5/7.5 mL at baseline is associated with decreased PFS (HR = 1.92) and OS (HR = 2.78). An elevated CTC count 3-5 weeks and 6-8 weeks after treatment commences is also associated with decreased PFS (HR = 1.85 and 2.20) and OS (HR = 2.26 and 2.91).

Infliximab effective in treatment of plaque-type psoriasis

As reported in the British Journal of Dermatology, of patients with plaque-type psoriasis (n=660) treated with infliximab (5 mg/kg) at weeks 0, 2, and 6, then q 8 weeks through week 50, 56.8% achieved PASI 75, 71.6% of whom maintained the response through week 98. Of patients who achieved PASI 75 by week 14, 64.7% maintained the response through week 50. Of patients who did not achieve PASI 75 by week 50, 66.3% achieved PASI 75 by week 98.

Hospital readmission rate in patients discharged on parenteral antibiotics

As reported in Clinical Infectious Diseases, the hospital readmission rate for patients (n=782) discharged on parenteral antibiotics was 26%. The mean patient age was 58 years. The leading diagnoses were bacteremia, osteomyelitis, and pyelonephritis. The indications for readmission included non-infection related (30%), worsening symptoms (29%), and new infections (19%). The ORs for readmission factors were as follows: each decade increase in age, 1.09; aminoglycoside use, 2.33; resistant organism, 1.57; and number of hospital discharges in prior 12 months, 1.20.

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