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Adverse myocardial effects of B-vitamin therapy in subjects with chronic kidney disease and hyperhomocysteinaemia
Nutrition, Metabolism & Cardiovascular Diseases, 08/21/2012
Rafeq Z et al. – Hyperhomocysteinaemia (HHCY) is associated with diastolic dysfunction in patients with chronic kidney disease (CKD). However, B–vitamin therapy did not improve HF outcomes despite lowering of plasma HCY levels, and was associated with an increase in left atrial size, which is a surrogate for worsening left ventricular diastolic dysfunction. These findings suggest that high–dose B vitamin therapy may be harmful in patients with CKD.