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Extra-Abdominal Desmoid Tumours: A Review of the Literature
Sarcoma, 08/21/2012
Molloy AP et al. – Extra–abdominal desmoid lesions, although benign, can cause significant disability to patients when they encase surrounding nerves and vasculature. Surgery, the traditional management option, has always been associated with increased recurrence rates. Given the benign nature of the disease, there has been increased research into the nonoperative management options. These lesions are slow growing and by definition should not respond to chemotherapy. However, it appears to have numerous potential receptor targets that permit the use of both cytotoxic and non–cytotoxic chemotherapeutic agents, with positive results.