Influenza A Viruses Target Type II Pneumocytes in the Human Lung
The Journal of Infectious Diseases, 08/17/2012
Weinheimer VK et al. – These findings show that differences in the pathogenic potential of influenza A viruses in the human lung cannot be attributed to a distinct cellular tropism. Rather, high or low viral pathogenicity is associated with a strain–specific capacity to productively replicate in type II pneumocytes and to cope with the induced cytokine response.