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Maternal and fetal serum orexin-A levels in gestational diabetes mellitus
Journal of Obstetrics and Gynaecology Research, 08/17/2012
Clinical Article
Yilmaz E et al. – Maternal serum orexin–A (OXA) levels decrease, and fetal serum OXA levels increase in women with gestational diabetes mellitus (GDM).
Methods- Thirty–five pregnant women with GDM and 35 gestational–age–matched healthy pregnant subjects participated in the study.
- Maternal serum and cord blood OXA levels were measured with enzyme immunoassay at the time of birth.
- The correlations between maternal serum and cord blood OXA levels, anthropometric and metabolic parameters were also assessed.
- The mean maternal and cord serum OXA (1.16 ± 0.37 and 1.35 ± 0.20 ng/mL, respectively) in the GDM group were significantly different from those of the controls (1.58 ± 0.59 and 1.25 ± 0.21 ng/mL, respectively).
- The mean maternal fasting–glucose–to–OXA ratio was significantly higher in the GDM group.
- In the GDM group, the mean maternal serum OXA levels were similar in the insulin (n = 24) and diet (n = 11) treated cases, respectively (1.13 ± 0.36 ng/mL and 1.21 ± 0.41 ng/mL).
- Maternal serum OXA levels positively correlated with fetal serum OXA and maternal glucose levels.
- OXA concentrations in maternal serum were negatively correlated with the fasting glucose, fasting insulin and homeostasis model assessment insulin resistance index.