A potency of plasminogen activation system in long-term prognosis of endometrial cancer: a pilot study
European Journal of Obstetrics & Gynecology and Reproductive Biology, 08/17/2012
Dariusz S et al. – A significantly higher immunohistochemical expression of PAI–1 was found to correlate with shorter relapse–free and overall survival in patients classified as stages IB and II of endometrial cancer.Methods
- The study group was composed of 100 patients classified in three sub–groups according to the FIGO 2010 tumour stratification (G1=70, G2=19, G3=11)..
- Expression of uPA, tPA, uPAR and PAI–1 was examined by means of immunohistochemical staining
- Immunohistochemical expressions of all the studied markers did not differ between G1 and G2 patients.
- However, G3 subjects were found to have a significantly lower expression of uPA, PAI–1 and tPA.
- In addition, the patients who survived were found to be PAI–1 negative, while study participants with an unfavourable disease course were PAI–1 positive.