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Cocktail sedation containing propofol versus conventional sedation for ERCP: a prospective, randomized controlled study Full Text
BMC Anesthesiology, 08/10/2012
Clinical Article
Angsuwatcharakon P et al. – Cocktail sedation containing propofol provides faster recovery time and better patients' satisfaction for patients undergoing ERCP. However, mild degree of desaturation may still develop.
Methods- ERCP patients were randomized into 2 groups; the cocktail group (n=103) and the controls (n=102).
- For induction, a combination of 25mg of meperidine and 2.5mg of midazolam were administered in both groups.
- In the cocktail group, a bolus dose of propofol 1mg/kg was administered and continuously infused.
- In the controls, 25mg of meperidine or 2.5mg/kg of midazolam were titrated to maintain the level of sedation.
- In the cocktail group, the average administration rate of propofol was 6.2mg/kg/hr.
- In the control group; average weight base dosage of meperidine and midazolam were 1.03mg/kg and 0.12mg/kg, respectively.
- Recovery times and patients' satisfaction scores in the cocktail and control groups were 9.67minutes and 12.89minutes (P=0.045), 93.1and 87.6 (P<0.001), respectively.
- Desaturation rates in the cocktail and conventional groups were 58.3% and 31.4% (P<0.001), respectively.
- All desaturations were corrected with temporary oxygen supplementation without the need for scope removal.