The Effect of Walking on Postprandial Glycemic Excursion in Patients With Type 1 Diabetes and Healthy People
Diabetes Care, 08/10/2012
Manohar C et al. – Walking significantly impacts postprandial glucose excursions in healthy populations and in those with type 1 diabetes. Artificial endocrine pancreas (AEP) algorithms incorporating Physical activity (PA) may enhance tight glycemic control end points.Methods
- The authors studied 12 healthy control subjects (five males, 37.7 ± 13.7 years of age) and 12 patients with type 1 diabetes (five males, 37.4 ± 14.2 years of age) for 88 h.
- Participants performed PA approximating a threefold increase over their basal metabolic rate.
- PA was captured using a PA–monitoring system, and interstitial fluid glucose concentrations were captured with continuous glucose monitors.
- In random order, one meal per day was followed by inactivity, and the other meals were followed by walking.
- Glucose and PA data for a total of 216 meals were analyzed from 30 min prior to meal ingestion to 270 min postmeal.
- In healthy subjects, the incremental glucose area under the curve was 4.5 mmol/L/270 min for meals followed by walking, whereas it was 9.6 mmol/L/270 min (P = 0.022) for meals followed by inactivity.
- The corresponding glucose excursions for those with type 1 diabetes were 7.5 mmol/L/270 min and 18.4 mmol/L/270 min, respectively (P < 0.001).