Regulation of paracellular transport in the distal nephron
Current Opinion in Nephrology and Hypertension, 08/10/2012
Hou J – The paracellular pathway in the collecting duct is an important route for transepithelial Cl- reabsorption that determines the extracellular NaCl content and the blood pressure. In the collecting duct cells, claudin–4 and claudin–8 interact to form a paracellular Cl- channel, whereas claudin–7 maintains the transepithelial resistance. Different subsets of the claudin family proteins fulfill diverse aspects of the tight junction function that will be fundamental to understanding the physiology of the paracellular pathway.