AMP-activated protein kinase regulation of kidney tubular transport
Current Opinion in Nephrology and Hypertension, 08/10/2012
Pastor–Soler NM et al. – The energy–sensing kinase AMP–activated protein kinase (AMPK) has a growing list of pleiotropic effects on cells and tissues, including its key role in the coupling of membrane transport to metabolic status in epithelial tissues like the kidney. AMPK is also involved in the coordination of hormonal, inflammatory, and other cellular stress pathway signals to produce an integrated effect on tubular transport. Identifying and characterizing new transport protein targets of AMPK should yield valuable new insights into various physiological and pathological processes in the kidney.