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Migraine, weight gain and the risk of becoming overweight and obese: A prospective cohort study
Cephalalgia, 08/21/2012
Clinical Article
Winter AC et al. - Results of this large prospective study of middle-aged women do not indicate a consistent association between migraine and incident overweight, obesity or relevant weight gain.
Methods- The authors conducted a prospective cohort study among 19,162 participants in the Women’s Health Study who had a body mass index (BMI) of 18.5-<25kg/m2 at baseline.
- Migraine was self-reported by standardized questionnaires.
- Main outcome measures were incident overweight (BMI ≥25kg/m2), incident obesity (BMI ≥30kg/m2) and mean weight change.
- Age- and multivariable-adjusted hazard ratios (HRs) were calculated for the association between migraine and incident overweight and obesity.
- Differences in weight change were evaluated by analysis of covariance (ANCOVA).
- A total of 3,483 (18.2%) women reported any migraine history.
- After 12.9 years of follow-up, 7916 incident overweight and 730 incident obesity cases occurred.
- Migraineurs had multivariable-adjusted HRs (95% confidence interval) of 1.11 (1.05-1.17) for becoming overweight and 1.00 (0.83-1.19) for becoming obese.
- These associations remained stable after censoring for chronic diseases and were similar according to migraine aura status.
- Multivariable-adjusted mean weight change from baseline to the end of study was +4.7kg for migraineurs and +4.4kg for women without migraine (p=0.02).