Baseline Levels of Soluble CD14 and CD16+56- Natural Killer Cells Are Negatively Associated With Response to Interferon/Ribavirin Therapy During HCV-HIV-1 Coinfection
The Journal of Infectious Diseases, 08/08/2012
Anthony DD et al. – Baseline sCD14 positively correlated with baseline HCV level and CD16+56– NK–cell frequency, and both sCD14 and CD16+56- NK cells correlated negatively with magnitude of HCV decline. IL28B genotype was associated with therapy response but not sCD14 or CD16+56- NK frequency. Markers of innate immune activation predict poor host response to IFN–α–based HCV therapy during HCV–HIV coinfection.