Islet-1 gene delivery improves myocardial performance after experimental infarction
Barzelay A et al. – Isl1 gives rise to subpopulations of progenitors in both the bone marrow and spleen, and is re–expressed in the spleen and left ventricle following MI. Intramyocardial gene transfer of Isl1 to the border zone of the infarcted hearts resulted in partial salvage of left ventricular function, enhanced vascularization, and reduced myocardial fibrosis. The Isl1 gene appears to be an attractive reparative target for future management of myocardial dysfunction.