Comparison of viral vectors for gene transfer to corneal endothelial cells
Acta Ophthalmologica, 08/17/2012
Fuchsluger T – DNA transfer using adeno–associated viral vectors (AAV) vectors seems to be an appropriate alternative to lentiviral vectors for gene transfer to EC. Relating to the cultivation of human donor corneas in eye banks over weeks, translation of AAV from bench to bedside, e.g. to reduce apoptosis in corneas, seems to be a promising approach for future gene transfer into donor corneas.