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Effect of the Pringle maneuver on tumor recurrence of hepatocellular carcinoma after curative resection (EPTRH): a randomized, prospective, controlled multicenter trial Full Text
BMC Cancer, 08/09/2012
Clinical Article
xiaobin F et al. – The results will increase the available information about the effects of ischemia–reperfusion injury on tumor recurrence, which will be of immense benefit to general surgery.
Methods- At least 498 eligible patients from five participating centers will be enrolled and randomized into either the Pringle group or the non-Pringle group in a ratio of 1:1 using a permuted-blocks randomization protocol.
- After the completion of surgical intervention, patients will be included in a 3-year follow-up program.
- This multicenter surgical trial will examine whether the Pringle maneuver has a negative effect on the long-term outcome of hepatocellular carcinoma patients.
- The trial will also provide information about prognostic differences, safety, advantages and disadvantages between Pringle and non-Pringle surgical procedures.