Secretory Leukocyte Proteinase Inhibitor-Competent DNA Deposits Are Potent Stimulators of Plasmacytoid Dendritic Cells: Implication for Psoriasis
The Journal of Immunology, 08/08/2012
Skrzeczynska–Moncznik J et al. – IFN type I (IFNI) synthesis by stimulated pDCs was dependent on intracellular DNA receptor TLR9. Thus, SLPI may contribute to psoriasis by enabling plasmacytoid dendritic cells (pDCs) to sense extracellular DNA and produce IFNI.