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Effect of antidepressive therapy on retinal contrast processing in depressive disorder
The British Journal of Psychiatry, 08/02/2012
Clinical Article
Bubl E et al. – The study provides evidence for a state–dependent modulation of retinal contrast gain in patients with major depression. Reduced contrast gain normalised after therapy. A pattern electroretinogram (PERG)–based contrast gain could serve as a state marker of depression.
Methods- Fourteen patients diagnosed with major depression were repeatedly scanned and the results compared with that from 40 matched controls.
- The retinal contrast gain was lower at baseline in patients with depression, was normalised with remission and correlated with the severity of depression.
- Patients who did not achieve remission retained significantly lower contrast gain at follow–up.