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Prooxidant-Antioxidant Balance and Antioxidized LDL Antibody Level Values and Cardiac Function in Patients with Coronary Artery Disease
Cardiology, 08/09/2012
Clinical Article
Rahsepar AA et al. – Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. Prooxidant–antioxidant balance (PAB) is a relatively simple index that could be incorporated into risk assessment in Coronary Artery Disease (CAD) patients. Anti–oxidized LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB.
Methods- Fifty–five patients with established CAD were selected, and serum levels of anti–ox–LDL IgG and PAB values were measured and compared with 40 matched healthy controls.
- Systolic and diastolic functions were determined for all patients.
- PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti–ox–LDL concentrations were not statistically different between the 2 groups (p = 0.821).
- However, after adjustment for high–density lipoprotein cholesterol, the patients had higher anti–ox–LDL levels (p = 0.04).
- Total PAB values were inversely associated with ejection fraction (r = –0.326, p = 0.031), but this was not the case for anti–ox–LDL in either group (p > 0.05).